If Voyager 1 was headed for Proxima Centauri, it would take 73,000 years to reach it. Could we create a mobile and independent colony that could survive that long? Or would it need a boost in speed, so that journey could be shortened?
How many breeding pairs of humans would be required? https://nu.federati.net/url/292680 [www technologyreviews com] (based on latest technology, so projected time is 6,300 years). Does not discuss the other creatures that would have to be carried.